pre:
Berserk - Melee weapons only. Large health globes act as berserk packs.
Marksmanship - Pistols only.
Shotgunnery - Shotguns only.
Light Travel - 5 inventory slots. Speed bonus.
Impatience - Consumables are used immediately when picked up.
Confidence - Skip episode 1.
Purity - No powerups.
Red Alert - Five minutes after you enter each level, it's nuked.
Darkness - Vision range reduced. No map memory. Double XP gain.
Max Carnage - Player and enemies always hit and always roll max damage.
Masochism - No healing except a Supercharge on level up.
100 - 100 randomly generated levels.
Pacifism - Cannot attack, but level up every 3 staircases.
Humanity - Start with 10 rather than 50 HP.
Overconfidence - Skip episodes 1 and 2.